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تشکیل بافت گرانولاسیون
Recent studies using selective depletion of macrophages during repair of skin, liver, kidney, heart, skeletal muscle and other tissues have demonstrated multiple critical functions, including regulation of angio- genesis, granulation tissue formation and extracellular matrix assembly [4,9-12].
Pro-wound healing macrophages produce elevated levels of growth factors such as PDGF, insulin-like growth factor 1 (IGF-1), VEGF and TGF-β1 (Murray and Wynn, 2011; Vannella and Wynn, 2017), which aid in cellular proliferation, granulation tissue formation, and angiogenesis.
These include decreased nerve count, angiogenesis, granulation tissue formation, and collagen content compared to acute wounds.
This suggests that macrophages are the first-responders to PDGF treatment, and in response, they must activate fibroblasts, via TGF-β, to proliferate and synthesize collagen, which contributes to granulation tissue formation and
Keratinocyte- derived granulocyte-macrophage colony stimulating factor accelerates wound healing: stimulation of keratinocyte proliferation, granulation tissue formation, and vascularization.
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